Botswana is generally very safe for travelers, especially outside the main towns. Exercise the same precautions as you would back home, and don’t have valuables on show.
Avoid driving outside of towns at night - roads are not lit and vehicles are in danger of colliding with roaming wildlife.
Check boots and shoes for critters before putting them on – especially if camping.
Homosexuality, while not illegal in Botswana, is still stigmatized. Same-sex couples are therefore advised to act discretely in public.